This downloadable scientific poster highlights breakthrough data showing that conventional planar MEAs can distort organoid morphology and lose activity over time, while the Mesh MEA’s integrated scaffold preserves structure, synapses, and functional network activity across weeks of culture.
By measuring Gem absorbance at 269 nm, the Biowave enabled precise determination of unencapsulated drug and calculation of EE%. Such reproducible spectrophotometric data was critical in validating formulation design, ensuring nanoparticle stability, and correlating entrapment with downstream release kinetics.
For this study, mature cerebral organoids (6-7 months old) were transferred to a Mesh MEA using a polyethyleneimine and laminin coating protocol and BrainPhys cell culture media. After 3 weeks in culture, COs displayed higher electrical activity on the Mesh MEA compared to planar MEA chips, which contained either flat or 3D-spike electrodes.
In the Abilez et al. study, the HEKA EPC 10 Patch Clamp Amplifier provided the sensitivity, stability, and control needed to investigate individual cells within the complex 3D environment of the organoid.
These findings demonstrate how electroporation can enhance the effectiveness of immunotherapies, offering a promising path for more potent and durable cancer treatments.
Funding bodies increasingly favor research that integrates in vitro and in vivo approaches for full translational impact. Discover how Harvard Bioscience’s comprehensive portfolio—from molecular assays to whole-animal models—supports rigorous, reproducible science aligned with today’s funding priorities. Build seamless workflows, strengthen grant proposals, and accelerate your path from bench to bedside with a single trusted partner.
Using advanced genetic and biochemical techniques, the researchers developed a fluorescently labeled tubulin system that enables real-time visualization of MT growth and organization in live cells. This approach provides new insights into the spatiotemporal regulation of MT dynamics, shedding light on fundamental cellular processes such as mitosis and intracellular transport.
Often overlooked in favour of simpler, outdated methods like Kjeldahl for protein content estimations, AAA provides the specificity, accuracy, and insight needed to meet both regulatory standards and consumer expectations in the alt-protein space.
Through our collaboration with Multi Channel Systems, the Ophthalmology Department at Radboudumc in the Netherlands is utilizing Mesh MEAs to capture dynamic retinal activity.
In microbiology, shortcuts often come at the expense of precision. Whether you're culturing E. coli for recombinant protein production, studying environmental microbes or brewing beer, building and using a proper growth curve ensures your results are as robust as your science demands.
