Organoid electrophysiology is providing pharmaceutical and biotech companies with human-relevant models for testing drug efficacy, modeling diseases, and reducing reliance on animal studies, ultimately accelerating the development of safer and more effective therapeutics.
In this study, the BTX ECM 830 electroporator was used to deliver CRISPR-Cas9 ribonucleoprotein (RNP) complexes and donor DNA templates into human CD34+ hematopoietic stem and progenitor cells (HSPCs) via electroporation.
Discover how to confidently design and execute microdialysis experiments with this practical guide. The Microdialysis Starter Kit ebook covers core concepts, real-world applications, system components, and expert tips to help you collect high-quality data in brain or peripheral tissues. Ideal for new and experienced researchers alike, it’s your go-to resource for reducing variability, increasing reproducibility, and unlocking localized biochemical insight.
By combining advanced genetic tools with precise electroporation technology, this study highlights not only the biological significance of Elp3 but also demonstrates the essential role of BTX's ECM 830 system in facilitating cutting-edge neuroscience research.
Discover how DSI’s SoHo™ Telemetry System and Panlab behavioral platforms empower Alzheimer’s researchers with synchronized physiological and behavioral data collection. This integrated approach enhances study design, data quality, and insight into disease progression—supporting breakthroughs in preclinical models. In honor of Alzheimer’s Awareness Month, explore how these advanced tools bring you closer to translational success.
Song et al. (2025) conducted a comprehensive genetic analysis of the live-attenuated SA14-14-2 vaccine and its virulent parent strain SA14, identifying key viral factors responsible for their differences in pathogenicity, which could inform future antiviral strategies and broader neurotropic virus research.
The photoelectrochemical research team from the School of Chemistry and Chemical Engineering, led by Professor Chen Shu, Associate Professor Zhang Jie, and Associate Professor Liu Canjun, plan to integrate it with their research focused on single-particle electrochemistry, photo/electrocatalysis, electrochemical sensing, in vivo electroanalytical chemistry, and other biomedical application fields, making it an electrophysiology-electrochemistry multi-function combined platform.
Organoid research is revolutionizing our understanding of human biology by providing three-dimensional, physiologically relevant models of human tissues. Key techniques include patch clamp electrophysiology, microelectrode arrays (MEAs), and optical manipulation, each of which unique advantages for studying the functional properties of organoids.
A recent Eli Lilly study highlights Jacketed External Telemetry (JET) as the superior method for nonclinical QTc assessment, outperforming multilead snapshot recordings in both statistical and pharmacological sensitivity. JET’s ability to capture high-fidelity ECG data from conscious, freely moving animals makes it more clinically relevant and regulatory-aligned. Backed by 2022 ICH E14/S7B updates, JET sets a new standard for cardiac safety in toxicology studies.
Our free guide compiles a range of experimental protocols to help guide researchers through the processes of culturing and seeding different types of organoids.
