Foresee IntraCell & MCS MEA Systems

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IntraCell & MCS MEA Systems

IntraCell & MCS MEA Systems

We’ve partnered with Foresee Biosystems to combine groundbreaking technologies that set new standards for intracellular electrophysiology. IntraCell is a laser-based optoporation system that, when used in conjunction with a Multi Channel Systems microelectrode array (MEA) system, allows researchers to capture high-quality intracellular action potentials (APs) from both 2D cardiac monolayers and 3D cardiac organoids.

IntraCell offers new opportunities in acute and especially chronic cardiotoxicology and safety pharmacology studies, enabling repeated recording sessions for 35+ days within the same cells without compromising their viability.

Our solution integrates the IntraCell unit with our latest MCS MEA systems, along with the corresponding software tools designed for precise data analysis. Our PhD experts are available to help you choose the right instrumentation for your unique research needs.

Description

The IntraCell system uses an ultra-short-pulsed laser to create transient nanopores in the membranes of cardiac cells cultured on a MEA. This process allows the recording of action potentials (APs) from the cells.

The laser alignment and scanning process is fully automated and guided by the software, and specific MEA layouts and electrodes can be selected for the recordings.

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IntraCell’s advanced technology facilitates detailed analysis of cardiac cell behavior, including real-time video recordings and contractility measurements, and is a powerful tool for studying the effects of various compounds on heart cells.

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Benefits
  • HIGH RESOLUTION: IntraCell technology allows for the measurement of intracellular action potentials simultaneously from several MEA electrodes, up to 256 parallel recordings.
  • LOW INVASIVENESS: The innovative technique of optoporation, which is used to locally open nanopores in the cell membrane, does not have a significant impact on cell viability over an extended time.
  • LONG-TERM RECORDINGS: You can study the electrophysiology of the same cells on top of an electrode for over 35 days, analyzing the variations of the action potential over time at different conditions.
  • REAL-TIME IMAGING: The integrated video microscope enables brightfield imaging of the cells as well as the observation and documentation of the rhythmic contraction of the cardiac myocytes.
  • EXCITATION-CONTRACTION COUPLING: By measuring simultaneously APs and contractility in the same experiment, you can easily study the excitation-contraction (E-C) coupling of the heart.
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